Prolotherapy

Targeted injections intended to stimulate repair in ligaments, tendons, and joints. What the approach involves and what to ask before you start.

Researched and edited by Rob MartinezNot medically reviewed. No clinician has reviewed this page. Why that mattersLast updated 2026-09-17

Regulatory and evidence status

Evidence varies by condition and is still developing. Ask a provider what the research supports for your specific situation.

What it is

Prolotherapy involves a series of injections, often a dextrose-based solution, intended to prompt a localized repair response in ligaments, tendons, and joints. It is typically offered as a course rather than a single visit.

It is most associated with chronic joint and connective-tissue concerns where instability or laxity is part of the picture. Because it is delivered over multiple sessions, understanding the plan and the expected timeline up front matters.

What providers commonly offer it for

  • Chronic ligament and tendon laxity
  • Joint instability
  • Persistent back and neck discomfort some providers address this way

What a first visit usually involves

  1. An assessment of the joint or connective tissue involved.
  2. A treatment plan that usually spans several sessions.
  3. Each session is a set of targeted injections at the site.
  4. Review points along the way to judge whether to continue.

Questions to ask a provider

  • How many sessions do you expect, and over what timeline?
  • What solution do you use, and why?
  • How will we know whether it is working?
  • What are the risks and the recovery between sessions?

Prolotherapy: common questions

How is prolotherapy different from PRP?
Both are injection-based, but prolotherapy commonly uses a dextrose-based solution rather than a preparation from your own blood. A provider can explain which they recommend and why.
How many sessions does it take?
It is typically a course rather than a one-off. Ask the provider for an expected number and timeline before you commit.
Is it painful?
It involves injections, so some discomfort is normal. Ask how they manage it and what recovery between sessions looks like.

This page describes a treatment, not any one clinic's version of it, and it is information rather than medical advice. Read the editorial policy.